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In a 2026 editorial commentary published in Cureus , citing findings from the STEP 4 and SURMOUNT 4 clinical trials, the author described how stopping GLP-1 medication may unmask counter-regulatory hunger signals including potential changes in ghrelin activity that had been suppressed while the medication was active (Quimbayo-Cifuentes, 2026)

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Particles or floaters: Hold the vial up to a light source and look carefully